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Charybdotoxin /ChTx
簡(jiǎn)要描述：Smartox Biotechnology是*一家專(zhuān)門(mén)生產(chǎn)動(dòng)物毒液多肽毒素，用于細(xì)胞離子通道功能研究的生物醫(yī)藥公司。多肽毒素在生物制藥領(lǐng)域具有重要的使用價(jià)值。
產(chǎn)品型號(hào)：11CHA001- 廠商性質(zhì)：代理商
- 更新時(shí)間：2025-07-02
- 訪 問(wèn) 量：2006
產(chǎn)品介紹
Charybdotoxin /ChTx
KCa2+ channel blocker(KCa2+ 通道阻斷劑)
Charybdotoxin (ChTx) is a 37 amino acid peptide isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus that blocks voltage-gated and large conductance Ca2+ activated K+ channels KCa1.1 in nanomolar concentrations (IC50~ 3 nM). This blockade causes hyperexcitability of the nervous system. The toxin reversibly blocks channel activity by interacting at the external pore of the channel protein with an apparent Kd of 2.1 nM. ChTX also blocksKCa3.1 (IC50 5 nM), Kv1.2 (IC50 14 nM), Kv1.3 (IC50 2.6 nM) and Kv1.6 (IC50 2 nM) channels.
ChTx技術(shù)資料
氨基酸序列：
H-Pyr-Phe-Thr-Asn-Val-Ser-Cys7-Thr-Thr-Ser-Lys-Glu-Cys13-Trp-Ser-Val-Cys17-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys28-Met-Asn-Lys-Lys-Cys33-Arg-Cys35-Tyr-Ser-OH
二硫鍵：Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35
長(zhǎng)度（aa）： 37
分子式：C176H277N57O55S7
分子量： 4295.90 Da
外觀：White lyophilized solid
可溶性： water and saline buffer
CAS 號(hào)：95751-30-7
來(lái)源：Synthetic
純度：> 97%
產(chǎn)品信息
11CHA001-00050 | Charybdotoxin | 0.05mg |
11CHA001-00100 | Charybdotoxin | 0.1mg |
11CHA001-00500 | Charybdotoxin | 0.5mg |
11CHA001-01000 | Charybdotoxin | 1mg |
